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The Eeee Locus Is the Sole High-Affinity Ca(2+) Binding Structure in the Pore of a Voltage-Gated Ca(2+) Channel: Block by Ca(2+) Entering from the Intracellular Pore Entrance
Selective permeability in voltage-gated Ca(2+) channels is dependent upon a quartet of pore-localized glutamate residues (EEEE locus). The EEEE locus is widely believed to comprise the sole high-affinity Ca(2+) binding site in the pore, which represents an overturning of earlier models that had post...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2000
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233694/ https://www.ncbi.nlm.nih.gov/pubmed/10962013 |