Severed Channels Probe Regulation of Gating of Cystic Fibrosis Transmembrane Conductance Regulator by Its Cytoplasmic Domains

Opening and closing of a CFTR Cl(−) channel is controlled by PKA-mediated phosphorylation of its cytoplasmic regulatory (R) domain and by ATP binding, and likely hydrolysis, at its two nucleotide binding domains. Functional interactions between the R domain and the two nucleotide binding domains wer...

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Detalles Bibliográficos
Autores principales: Csanády, László, Chan, Kim W., Seto-Young, Donna, Kopsco, David C., Nairn, Angus C., Gadsby, David C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233695/
https://www.ncbi.nlm.nih.gov/pubmed/10962022

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