Mechanism of Block of Single Protopores of the Torpedo Chloride Channel Clc-0 by 2-(p-Chlorophenoxybutyric) Acid (Cpb)

We investigated in detail the mechanism of inhibition by the S(−) enantiomer of 2-(p-chlorophenoxy)butyric acid (CPB) of the Torpedo Cl(−) channel, ClC-0. The substance has been previously shown to inhibit the homologous skeletal muscle channel, CLC-1. ClC-0 is a homodimer with probably two independ...

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Detalles Bibliográficos
Autores principales: Pusch, Michael, Accardi, Alessio, Liantonio, Antonella, Ferrera, Loretta, De Luca, Annamaria, Camerino, Diana Conte, Conti, Franco
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233749/
https://www.ncbi.nlm.nih.gov/pubmed/11432801

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