Cargando…
Intracellular Mg(2+) Enhances the Function of Bk-Type Ca(2+)-Activated K(+) Channels
BK channels modulate neurotransmitter release due to their activation by voltage and Ca(2+). Intracellular Mg(2+) also modulates BK channels in multiple ways with opposite effects on channel function. Previous single-channel studies have shown that Mg(2+) blocks the pore of BK channels in a voltage-...
Autores principales: | Shi, Jingyi, Cui, Jianmin |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2001
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233844/ https://www.ncbi.nlm.nih.gov/pubmed/11696614 |
Ejemplares similares
-
The NH(2) Terminus of RCK1 Domain Regulates Ca(2+)-dependent BK(Ca) Channel Gating
por: Krishnamoorthy, Gayathri, et al.
Publicado: (2005) -
Interaction between residues in the Mg(2+)-binding site regulates BK channel activation
por: Yang, Junqiu, et al.
Publicado: (2013) -
Activation of Slo1 BK channels by Mg(2+) coordinated between the voltage sensor and the RCK1 domains
por: Yang, Huanghe, et al.
Publicado: (2008) -
Mg(2+) Enhances Voltage Sensor/Gate Coupling in BK Channels
por: Horrigan, Frank T., et al.
Publicado: (2008) -
An allosteric modulator activates BK channels by perturbing coupling between Ca(2+) binding and pore opening
por: Zhang, Guohui, et al.
Publicado: (2022)