Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson's Disease by Repetitive Transcranial Magnetic Stimulation

We studied whether five sessions of 10 Hz repetitive transcranial magnetic stimulation (rTMS treatment) applied over the dorsolateral prefrontal cortex (DLPFC) or the primary motor cortex (MC) in advanced Parkinson's disease (PD) patients would have any effect on L-dopa-induced dyskinesias and...

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Autores principales: Rektorova, I., Sedlackova, S., Telecka, S., Hlubocky, A., Rektor, I.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233877/
https://www.ncbi.nlm.nih.gov/pubmed/18274665
http://dx.doi.org/10.1155/2008/372125
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author Rektorova, I.
Sedlackova, S.
Telecka, S.
Hlubocky, A.
Rektor, I.
author_facet Rektorova, I.
Sedlackova, S.
Telecka, S.
Hlubocky, A.
Rektor, I.
author_sort Rektorova, I.
collection PubMed
description We studied whether five sessions of 10 Hz repetitive transcranial magnetic stimulation (rTMS treatment) applied over the dorsolateral prefrontal cortex (DLPFC) or the primary motor cortex (MC) in advanced Parkinson's disease (PD) patients would have any effect on L-dopa-induced dyskinesias and cortical excitability. We aimed at a randomised, controlled study. Single-pulse transcranial magnetic stimulation (TMS), paired-pulse transcranial magnetic stimulation, and the Unified Parkinson's Disease Rating Scale (UPDRS parts III and IV) were performed prior to, immediately after, and one week after an appropriate rTMS treatment. Stimulation of the left DLPFC induced a significant motor cortex depression and a trend towards the improvement of L-dopa-induced dyskinesias.
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spelling pubmed-22338772008-02-14 Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson's Disease by Repetitive Transcranial Magnetic Stimulation Rektorova, I. Sedlackova, S. Telecka, S. Hlubocky, A. Rektor, I. Int J Biomed Imaging Research Article We studied whether five sessions of 10 Hz repetitive transcranial magnetic stimulation (rTMS treatment) applied over the dorsolateral prefrontal cortex (DLPFC) or the primary motor cortex (MC) in advanced Parkinson's disease (PD) patients would have any effect on L-dopa-induced dyskinesias and cortical excitability. We aimed at a randomised, controlled study. Single-pulse transcranial magnetic stimulation (TMS), paired-pulse transcranial magnetic stimulation, and the Unified Parkinson's Disease Rating Scale (UPDRS parts III and IV) were performed prior to, immediately after, and one week after an appropriate rTMS treatment. Stimulation of the left DLPFC induced a significant motor cortex depression and a trend towards the improvement of L-dopa-induced dyskinesias. Hindawi Publishing Corporation 2008 2007-11-26 /pmc/articles/PMC2233877/ /pubmed/18274665 http://dx.doi.org/10.1155/2008/372125 Text en Copyright © 2008 I. Rektorova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rektorova, I.
Sedlackova, S.
Telecka, S.
Hlubocky, A.
Rektor, I.
Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson's Disease by Repetitive Transcranial Magnetic Stimulation
title Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson's Disease by Repetitive Transcranial Magnetic Stimulation
title_full Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson's Disease by Repetitive Transcranial Magnetic Stimulation
title_fullStr Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson's Disease by Repetitive Transcranial Magnetic Stimulation
title_full_unstemmed Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson's Disease by Repetitive Transcranial Magnetic Stimulation
title_short Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson's Disease by Repetitive Transcranial Magnetic Stimulation
title_sort dorsolateral prefrontal cortex: a possible target for modulating dyskinesias in parkinson's disease by repetitive transcranial magnetic stimulation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233877/
https://www.ncbi.nlm.nih.gov/pubmed/18274665
http://dx.doi.org/10.1155/2008/372125
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