Cargando…
Stabilizing the Closed S6 Gate in the Shaker K (v) Channel Through Modification of a Hydrophobic Seal
The primary activation gate in K(+) channels is thought to reside near the intracellular entrance to the ion conduction pore. In a previous study of the S6 activation gate in Shaker (Hackos et al., 2002), we found that mutation of V478 to W results in a channel that cannot conduct ions even though t...
| Autores principales: | , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233904/ https://www.ncbi.nlm.nih.gov/pubmed/15365093 http://dx.doi.org/10.1085/jgp.200409098 |