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Mechanism of Block of hEag1 K(+) Channels by Imipramine and Astemizole

Ether à go-go (Eag; K(V)10.1) voltage-gated K(+) channels have been detected in cancer cell lines of diverse origin and shown to influence their rate of proliferation. The tricyclic antidepressant imipramine and the antihistamine astemizole inhibit the current through Eag1 channels and reduce the pr...

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Detalles Bibliográficos
Autores principales:	García-Ferreiro, Rafael E., Kerschensteiner, Daniel, Major, Felix, Monje, Francisco, Stühmer, Walter, Pardo, Luis A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233905/ https://www.ncbi.nlm.nih.gov/pubmed/15365094 http://dx.doi.org/10.1085/jgp.200409041

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