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Identification of the Ca(2+) Blocking Site of Acid-sensing Ion Channel (ASIC) 1: Implications for Channel Gating
Acid-sensing ion channels ASIC1a and ASIC1b are ligand-gated ion channels that are activated by H(+) in the physiological range of pH. The apparent affinity for H(+) of ASIC1a and 1b is modulated by extracellular Ca(2+) through a competition between Ca(2+) and H(+). Here we show that, in addition to...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233906/ https://www.ncbi.nlm.nih.gov/pubmed/15452199 http://dx.doi.org/10.1085/jgp.200308973 |