Administration of PDE4 Inhibitors Suppressed the Pannus-Like Inflammation by Inhibition of Cytokine Production by Macrophages and Synovial Fibroblast Proliferation

A marked proliferation of synovial fibroblasts in joints leads to pannus formation in rheumatoid arthritis (RA). Various kinds of cytokines are produced in the pannus. The purpose of this study is to elucidate the effects of phosphodiesterase 4 (PDE4) inhibitors in a new animal model for the evaluat...

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Detalles Bibliográficos
Autores principales: Kobayashi, Katsuya, Suda, Toshio, Manabe, Haruhiko, Miki, Ichiro
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233982/
https://www.ncbi.nlm.nih.gov/pubmed/18274640
http://dx.doi.org/10.1155/2007/58901

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