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Arachidonic Acid Inhibits Epithelial Na Channel Via Cytochrome P450 (CYP) Epoxygenase-dependent Metabolic Pathways

We used the patch-clamp technique to study the effect of arachidonic acid (AA) on epithelial Na channels (ENaC) in the rat cortical collecting duct (CCD). Application of 10 μM AA decreased the ENaC activity defined by NPo from 1.0 to 0.1. The dose–response curve of the AA effect on ENaC shows that 2...

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Detalles Bibliográficos
Autores principales:	Wei, Yuan, Lin, Dao-Hong, Kemp, Rowena, Yaddanapudi, Ganesh S.S., Nasjletti, Alberto, Falck, John R., Wang, Wen-Hui
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234027/ https://www.ncbi.nlm.nih.gov/pubmed/15545402 http://dx.doi.org/10.1085/jgp.200409140

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