Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

Eosinophil-derived neurotoxin (EDN) is an eosinophil granule–derived secretory protein with ribonuclease and antiviral activity. We have previously shown that EDN can induce the migration and maturation of dendritic cells (DCs). Here, we report that EDN can activate myeloid DCs by triggering the Tol...

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Detalles Bibliográficos
Autores principales: Yang, De, Chen, Qian, Su, Shao Bo, Zhang, Ping, Kurosaka, Kahori, Caspi, Rachel R., Michalek, Suzanne M., Rosenberg, Helene F., Zhang, Ning, Oppenheim, Joost J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234357/
https://www.ncbi.nlm.nih.gov/pubmed/18195069
http://dx.doi.org/10.1084/jem.20062027

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