Alarming dendritic cells for Th2 induction

There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a dis...

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Detalles Bibliográficos
Autores principales: MacDonald, Andrew S., Maizels, Rick M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234366/
https://www.ncbi.nlm.nih.gov/pubmed/18195077
http://dx.doi.org/10.1084/jem.20072665
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author MacDonald, Andrew S.
Maizels, Rick M.
author_facet MacDonald, Andrew S.
Maizels, Rick M.
author_sort MacDonald, Andrew S.
collection PubMed
description There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.
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spelling pubmed-22343662008-07-21 Alarming dendritic cells for Th2 induction MacDonald, Andrew S. Maizels, Rick M. J Exp Med Commentaries There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs. The Rockefeller University Press 2008-01-21 /pmc/articles/PMC2234366/ /pubmed/18195077 http://dx.doi.org/10.1084/jem.20072665 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
MacDonald, Andrew S.
Maizels, Rick M.
Alarming dendritic cells for Th2 induction
title Alarming dendritic cells for Th2 induction
title_full Alarming dendritic cells for Th2 induction
title_fullStr Alarming dendritic cells for Th2 induction
title_full_unstemmed Alarming dendritic cells for Th2 induction
title_short Alarming dendritic cells for Th2 induction
title_sort alarming dendritic cells for th2 induction
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234366/
https://www.ncbi.nlm.nih.gov/pubmed/18195077
http://dx.doi.org/10.1084/jem.20072665
work_keys_str_mv AT macdonaldandrews alarmingdendriticcellsforth2induction
AT maizelsrickm alarmingdendriticcellsforth2induction

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