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Elimination of the BK(Ca) Channel's High-Affinity Ca(2+) Sensitivity

We report here a combination of site-directed mutations that eliminate the high-affinity Ca(2+) response of the large-conductance Ca(2+)-activated K(+) channel (BK(Ca)), leaving only a low-affinity response blocked by high concentrations of Mg(2+). Mutations at two sites are required, the “Ca(2+) bo...

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Detalles Bibliográficos
Autores principales:	Bao, Lin, Rapin, Anne M., Holmstrand, Ericka C., Cox, Daniel H.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234461/ https://www.ncbi.nlm.nih.gov/pubmed/12149279 http://dx.doi.org/10.1085/jgp.20028627

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