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Conotoxins as Sensors of Local pH and Electrostatic Potential in the Outer Vestibule of the Sodium Channel

We examined the block of voltage-dependent rat skeletal muscle sodium channels by derivatives of μ-conotoxin GIIIA (μCTX) having either histidine, glutamate, or alanine residues substituted for arginine-13. Toxin binding and dissociation were observed as current fluctuations from single, batrachotox...

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Detalles Bibliográficos
Autores principales:	Hui, Kwokyin, McIntyre, Deane, French, Robert J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234468/ https://www.ncbi.nlm.nih.gov/pubmed/12835471 http://dx.doi.org/10.1085/jgp.200308842

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