Cargando…

Molecular Motions of the Outer Ring of Charge of the Sodium Channel: Do They Couple to Slow Inactivation?

In contrast to fast inactivation, the molecular basis of sodium (Na) channel slow inactivation is poorly understood. It has been suggested that structural rearrangements in the outer pore mediate slow inactivation of Na channels similar to C-type inactivation in potassium (K) channels. We probed the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiong, Wei, Li, Ronald A., Tian, Yanli, Tomaselli, Gordon F.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234489/ https://www.ncbi.nlm.nih.gov/pubmed/12913092 http://dx.doi.org/10.1085/jgp.200308881

Ejemplares similares

A Structural Rearrangement in the Sodium Channel Pore Linked to Slow Inactivation and Use Dependence
por: Ong, Boon-Hooi, et al.
Publicado: (2000)

Sodium channel slow inactivation interferes with open channel block
por: Hampl, Martin, et al.
Publicado: (2016)

Role of Domain 4 in Sodium Channel Slow Inactivation
por: Mitrovic, Nenad, et al.
Publicado: (2000)

A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb
por: Gamal El-Din, Tamer M., et al.
Publicado: (2013)

Charged Residues between the Selectivity Filter and S6 Segments Contribute to the Permeation Phenotype of the Sodium Channel
por: Li, Ronald A., et al.
Publicado: (2000)

Functional consequences of lidocaine binding to slow-inactivated sodium channels
Publicado: (1996)

Slow sodium-channel inactivation underlies spike threshold variability
por: Harrison, Paul M, et al.
Publicado: (2013)

Slow Inactivation Does Not Block the Aqueous Accessibility to the Outer Pore of Voltage-gated Na Channels
por: Struyk, Arie F., et al.
Publicado: (2002)

Molecular Coupling of S4 to a K(+) Channel's Slow Inactivation Gate
por: Loots, Eli, et al.
Publicado: (2000)

Sodium Channel Inactivation Is Altered by Substitution of Voltage Sensor Positive Charges
por: Kontis, Kris J., et al.
Publicado: (1997)

The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation
por: Chatterjee, Soumili, et al.
Publicado: (2018)

Slow Inactivation of Sodium Channels Contributes to Short-Term Adaptation in Vomeronasal Sensory Neurons
por: Sarno, Nicole, et al.
Publicado: (2022)

Movement of Voltage Sensor S4 in Domain 4 Is Tightly Coupled to Sodium Channel Fast Inactivation and Gating Charge Immobilization
por: Kühn, Frank J.P., et al.
Publicado: (1999)

Correlation between Charge Movement and Ionic Current during Slow Inactivation in Shaker K(+) Channels
por: Olcese, Riccardo, et al.
Publicado: (1997)

Interaction of Scorpion α-Toxins with Cardiac Sodium Channels: Binding Properties and Enhancement of Slow Inactivation
por: Chen, Haijun, et al.
Publicado: (2001)

Kv1 channel inactivation: Slow and slower
por: Short, Ben
Publicado: (2022)

Regulation of K(+) Flow by a Ring of Negative Charges in the Outer Pore of BK(Ca) Channels. Part II: Neutralization of Aspartate 292 Reduces Long Channel Openings and Gating Current Slow Component
por: Haug, Trude, et al.
Publicado: (2004)

Slowing of sodium current inactivation by ruthenium red in snail neurons
Publicado: (1982)

Inactivation of the sodium channel. I. Sodium current experiments
por: Bezanilla, F, et al.
Publicado: (1977)

Independent Versus Coupled Inactivation in Sodium Channels : Role of the Domain 2 S4 Segment
por: Mitrovic, Nenad, et al.
Publicado: (1998)

Sodium Channel Inactivation Goes with the Flow
por: Kass, Robert S.
Publicado: (2004)

Measurement of slow closed-orbit motion in the HERA electron ring in correlation with ground motion
por: Decking, W, et al.
Publicado: (1990)

Fast and slow steps in the activation of sodium channels
Publicado: (1979)

Charge movement in the sodium channel
Publicado: (1995)

Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Na(v)1.4 in Its Slow-Inactivated State and Inhibits Sodium Current
por: Huang, Chiung-Wei, et al.
Publicado: (2021)

Slow sodium inactivation in nerve after exposure to sulhydryl blocking reagents
Publicado: (1977)

Protein Rearrangements Underlying Slow Inactivation of the Shaker K(+) Channel
por: Loots, E., et al.
Publicado: (1998)

Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium
por: González-Pérez, Vivian, et al.
Publicado: (2008)

Probing the Cavity of the Slow Inactivated Conformation of Shaker Potassium Channels
por: Panyi, Gyorgy, et al.
Publicado: (2007)

Extracellular Sodium Interacts with the HERG Channel at an Outer Pore Site
por: Mullins, Franklin M., et al.
Publicado: (2002)

The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel
por: Fozzard, Harry A., et al.
Publicado: (2010)

Inactivation viewed through single sodium channels
Publicado: (1984)

Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4–S5 linker in activation and slow inactivation
por: Xiao, Jinglei, et al.
Publicado: (2021)

Slow Inactivation Does Not Affect Movement of the Fast Inactivation Gate in Voltage-gated Na(+) Channels
por: Vedantham, Vasanth, et al.
Publicado: (1998)

S1–S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation
por: Groome, James R., et al.
Publicado: (2013)

Effect of Alkali Metal Cations on Slow Inactivation of Cardiac Na(+) Channels
por: Townsend, Claire, et al.
Publicado: (1997)

Recovery from Slow Inactivation in K(+) Channels is Controlled by Water Molecules
por: Ostmeyer, Jared, et al.
Publicado: (2013)

Structure of the Shaker Kv channel and mechanism of slow C-type inactivation
por: Tan, Xiao-Feng, et al.
Publicado: (2022)

Slow motion
por: Uchida, Naoshige, et al.
Publicado: (2017)

A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, Na(V)1.2
por: Abdelsayed, Mena, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_pud9bng80o81q94upsg8kce6sl