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Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities
BACKGROUND: Polychlorinated biphenyls (PCBs) may accelerate the cognitive and motor dysfunction found in normal aging, but few studies have examined these outcomes and PCB exposure among older adults. OBJECTIVE: We evaluated neuropsychological status and low-level PCB exposure among older adults liv...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235204/ https://www.ncbi.nlm.nih.gov/pubmed/18288320 http://dx.doi.org/10.1289/ehp.10432 |
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author | Fitzgerald, Edward F. Belanger, Erin E. Gomez, Marta I. Cayo, Michael McCaffrey, Robert J. Seegal, Richard F. Jansing, Robert L. Hwang, Syni-an Hicks, Heraline E. |
author_facet | Fitzgerald, Edward F. Belanger, Erin E. Gomez, Marta I. Cayo, Michael McCaffrey, Robert J. Seegal, Richard F. Jansing, Robert L. Hwang, Syni-an Hicks, Heraline E. |
author_sort | Fitzgerald, Edward F. |
collection | PubMed |
description | BACKGROUND: Polychlorinated biphenyls (PCBs) may accelerate the cognitive and motor dysfunction found in normal aging, but few studies have examined these outcomes and PCB exposure among older adults. OBJECTIVE: We evaluated neuropsychological status and low-level PCB exposure among older adults living along contaminated portions of the upper Hudson River in New York. METHODS: A total of 253 persons between 55 and 74 years of age were recruited and interviewed, and provided blood samples for congener-specific PCB analysis. Participants also underwent a neuropsychological battery consisting of 34 tests capable of detecting subtle deficits in cognition, motor function, affective state, and olfactory function. RESULTS: After adjustment for potential confounders, the results indicated that an increase in serum total PCB concentration from 250 to 500 ppb (lipid basis) was associated with a 6.2% decrease in verbal learning, as measured by California Verbal Learning Test trial 1 score (p = 0.035), and with a 19.2% increase in depressive symptoms, as measured by the Beck Depression Inventory (p = 0.007). CONCLUSIONS: The results suggest that exposure to PCBs may be associated with some measures of memory and learning and depression among adults 55–74 years of age whose current body burdens are similar to those of the general population. Although the results are useful in delineating the neuropsychological effects of low-level exposure to PCBs, further studies of whether older men and women are a sensitive subpopulation are needed. |
format | Text |
id | pubmed-2235204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-22352042008-02-20 Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities Fitzgerald, Edward F. Belanger, Erin E. Gomez, Marta I. Cayo, Michael McCaffrey, Robert J. Seegal, Richard F. Jansing, Robert L. Hwang, Syni-an Hicks, Heraline E. Environ Health Perspect Research BACKGROUND: Polychlorinated biphenyls (PCBs) may accelerate the cognitive and motor dysfunction found in normal aging, but few studies have examined these outcomes and PCB exposure among older adults. OBJECTIVE: We evaluated neuropsychological status and low-level PCB exposure among older adults living along contaminated portions of the upper Hudson River in New York. METHODS: A total of 253 persons between 55 and 74 years of age were recruited and interviewed, and provided blood samples for congener-specific PCB analysis. Participants also underwent a neuropsychological battery consisting of 34 tests capable of detecting subtle deficits in cognition, motor function, affective state, and olfactory function. RESULTS: After adjustment for potential confounders, the results indicated that an increase in serum total PCB concentration from 250 to 500 ppb (lipid basis) was associated with a 6.2% decrease in verbal learning, as measured by California Verbal Learning Test trial 1 score (p = 0.035), and with a 19.2% increase in depressive symptoms, as measured by the Beck Depression Inventory (p = 0.007). CONCLUSIONS: The results suggest that exposure to PCBs may be associated with some measures of memory and learning and depression among adults 55–74 years of age whose current body burdens are similar to those of the general population. Although the results are useful in delineating the neuropsychological effects of low-level exposure to PCBs, further studies of whether older men and women are a sensitive subpopulation are needed. National Institute of Environmental Health Sciences 2008-02 2007-11-12 /pmc/articles/PMC2235204/ /pubmed/18288320 http://dx.doi.org/10.1289/ehp.10432 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Fitzgerald, Edward F. Belanger, Erin E. Gomez, Marta I. Cayo, Michael McCaffrey, Robert J. Seegal, Richard F. Jansing, Robert L. Hwang, Syni-an Hicks, Heraline E. Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities |
title | Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities |
title_full | Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities |
title_fullStr | Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities |
title_full_unstemmed | Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities |
title_short | Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities |
title_sort | polychlorinated biphenyl exposure and neuropsychological status among older residents of upper hudson river communities |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235204/ https://www.ncbi.nlm.nih.gov/pubmed/18288320 http://dx.doi.org/10.1289/ehp.10432 |
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