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Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study

BACKGROUND: Persons of Pakistani origin living in Oslo have a much higher prevalence of vitamin D deficiency and secondary hyperparathyroidism but similar bone mineral density compared with ethnic Norwegians. Our objective was to investigate whether Pakistani immigrants living in Oslo have an altere...

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Autores principales: Holvik, Kristin, Meyer, Haakon E, Søgaard, Anne Johanne, Haug, Egil, Falch, Jan A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235861/
https://www.ncbi.nlm.nih.gov/pubmed/17945003
http://dx.doi.org/10.1186/1472-6823-7-9
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author Holvik, Kristin
Meyer, Haakon E
Søgaard, Anne Johanne
Haug, Egil
Falch, Jan A
author_facet Holvik, Kristin
Meyer, Haakon E
Søgaard, Anne Johanne
Haug, Egil
Falch, Jan A
author_sort Holvik, Kristin
collection PubMed
description BACKGROUND: Persons of Pakistani origin living in Oslo have a much higher prevalence of vitamin D deficiency and secondary hyperparathyroidism but similar bone mineral density compared with ethnic Norwegians. Our objective was to investigate whether Pakistani immigrants living in Oslo have an altered vitamin D metabolism by means of compensatory higher serum levels of 1,25-dihydroxyvitamin D (s-1,25(OH)(2)D) compared with ethnic Norwegians; and whether serum levels of ionized calcium (s-Ca(2+)) differ between Pakistanis and Norwegians. METHODS: In a cross-sectional, population-based study venous serum samples were drawn from 94 Pakistani men and 67 Pakistani women aged 30–60 years, and 290 Norwegian men and 270 Norwegian women aged 45–60 years; in total 721 subjects. RESULTS: Pakistanis had lower s-1,25(OH)(2)D compared with Norwegians (p < 0.001). Age- and gender adjusted mean (95% CI) levels were 93 (86, 99) pmol/l in Pakistanis and 123 (120, 126) pmol/l in Norwegians, p < 0.001. The difference persisted after controlling for body mass index. There was a positive relation between serum 25-hydroxyvitamin D (s-25(OH)D) and s-1,25(OH)(2)D in both groups. S-Ca(2+ )was higher in Pakistanis; age-adjusted mean (95% CI) levels were 1.28 (1.27, 1.28) mmol/l in Pakistanis and 1.26 (1.26, 1.26) mmol/l in Norwegians, p < 0.001. In both groups, s-Ca(2+ )was inversely correlated to serum intact parathyroid hormone levels (s-iPTH). For any s-iPTH, s-Ca(2+ )was higher in Pakistanis, also when controlling for age. CONCLUSION: Community-dwelling Pakistanis in Oslo with low vitamin D status and secondary hyperparathyroidism have lower s-1,25(OH)(2)D compared with ethnic Norwegians. However, the Pakistanis have higher s-Ca(2+). The cause of the higher s-Ca(2+ )in Pakistanis in spite of their higher iPTH remains unclear.
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spelling pubmed-22358612008-02-09 Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study Holvik, Kristin Meyer, Haakon E Søgaard, Anne Johanne Haug, Egil Falch, Jan A BMC Endocr Disord Research Article BACKGROUND: Persons of Pakistani origin living in Oslo have a much higher prevalence of vitamin D deficiency and secondary hyperparathyroidism but similar bone mineral density compared with ethnic Norwegians. Our objective was to investigate whether Pakistani immigrants living in Oslo have an altered vitamin D metabolism by means of compensatory higher serum levels of 1,25-dihydroxyvitamin D (s-1,25(OH)(2)D) compared with ethnic Norwegians; and whether serum levels of ionized calcium (s-Ca(2+)) differ between Pakistanis and Norwegians. METHODS: In a cross-sectional, population-based study venous serum samples were drawn from 94 Pakistani men and 67 Pakistani women aged 30–60 years, and 290 Norwegian men and 270 Norwegian women aged 45–60 years; in total 721 subjects. RESULTS: Pakistanis had lower s-1,25(OH)(2)D compared with Norwegians (p < 0.001). Age- and gender adjusted mean (95% CI) levels were 93 (86, 99) pmol/l in Pakistanis and 123 (120, 126) pmol/l in Norwegians, p < 0.001. The difference persisted after controlling for body mass index. There was a positive relation between serum 25-hydroxyvitamin D (s-25(OH)D) and s-1,25(OH)(2)D in both groups. S-Ca(2+ )was higher in Pakistanis; age-adjusted mean (95% CI) levels were 1.28 (1.27, 1.28) mmol/l in Pakistanis and 1.26 (1.26, 1.26) mmol/l in Norwegians, p < 0.001. In both groups, s-Ca(2+ )was inversely correlated to serum intact parathyroid hormone levels (s-iPTH). For any s-iPTH, s-Ca(2+ )was higher in Pakistanis, also when controlling for age. CONCLUSION: Community-dwelling Pakistanis in Oslo with low vitamin D status and secondary hyperparathyroidism have lower s-1,25(OH)(2)D compared with ethnic Norwegians. However, the Pakistanis have higher s-Ca(2+). The cause of the higher s-Ca(2+ )in Pakistanis in spite of their higher iPTH remains unclear. BioMed Central 2007-10-18 /pmc/articles/PMC2235861/ /pubmed/17945003 http://dx.doi.org/10.1186/1472-6823-7-9 Text en Copyright © 2007 Holvik et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Holvik, Kristin
Meyer, Haakon E
Søgaard, Anne Johanne
Haug, Egil
Falch, Jan A
Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study
title Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study
title_full Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study
title_fullStr Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study
title_full_unstemmed Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study
title_short Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study
title_sort pakistanis living in oslo have lower serum 1,25-dihydroxyvitamin d levels but higher serum ionized calcium levels compared with ethnic norwegians. the oslo health study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235861/
https://www.ncbi.nlm.nih.gov/pubmed/17945003
http://dx.doi.org/10.1186/1472-6823-7-9
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