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Presenilins are required for maintenance of neural stem cells in the developing brain
The early embryonic lethality of mutant mice bearing germ-line deletions of both presenilin genes precluded the study of their functions in neural development. We therefore employed the Cre-loxP technology to generate presenilin conditional double knockout (PS cDKO) mice, in which expression of both...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235867/ https://www.ncbi.nlm.nih.gov/pubmed/18182109 http://dx.doi.org/10.1186/1750-1326-3-2 |