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Effectiveness of low-dose doxycycline (LDD) on clinical symptoms of Sjögren's Syndrome: a randomized, double-blind, placebo controlled cross-over study

BACKGROUND: Matrix metalloproteinases (MMPs) are proteolytic enzymes that may contribute to tissue destruction in Sjögren's syndrome (SS). Low-dose doxycycline (LDD) inhibits MMPs. We evaluated the efficacy of LDD for the subjective symptoms in primary SS patients. This was a randomized, double...

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Detalles Bibliográficos
Autores principales:	Seitsalo, Hubertus, Niemelä, Raija K, Marinescu-Gava, Magdalena, Vuotila, Tuija, Tjäderhane, Leo, Salo, Tuula
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235889/ https://www.ncbi.nlm.nih.gov/pubmed/18163919 http://dx.doi.org/10.1186/1477-5751-6-11

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