THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII

1. The inhibition of oxygen consumption produced by a series of concentrations of ethyl carbamate has been measured in the protozoan Tetrahymena geleii. 2. The relation found between the narcotic concentration and its effect on respiration leads to the conclusion that urethane has two distinct modes...

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Autores principales: Ormsbee, Richard A., Fisher, Kenneth C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1944
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238023/
https://www.ncbi.nlm.nih.gov/pubmed/19873395
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author Ormsbee, Richard A.
Fisher, Kenneth C.
author_facet Ormsbee, Richard A.
Fisher, Kenneth C.
author_sort Ormsbee, Richard A.
collection PubMed
description 1. The inhibition of oxygen consumption produced by a series of concentrations of ethyl carbamate has been measured in the protozoan Tetrahymena geleii. 2. The relation found between the narcotic concentration and its effect on respiration leads to the conclusion that urethane has two distinct modes of action in this cell. The respiratory data can be accurately predicted by assuming that the inhibitor acts on two independent parallel respiratory systems. 3. Complete suppression of cell division in this organism is brought about by approximately 0.1 M urethane. 4. Urethane concentrations up to 0.1 M affect primarily only one of the two postulated respiratory systems. The mechanism of the narcosis of cell division in this organism by urethane thus appears to be inhibition of this "activity" system.
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spelling pubmed-22380232008-04-23 THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII Ormsbee, Richard A. Fisher, Kenneth C. J Gen Physiol Article 1. The inhibition of oxygen consumption produced by a series of concentrations of ethyl carbamate has been measured in the protozoan Tetrahymena geleii. 2. The relation found between the narcotic concentration and its effect on respiration leads to the conclusion that urethane has two distinct modes of action in this cell. The respiratory data can be accurately predicted by assuming that the inhibitor acts on two independent parallel respiratory systems. 3. Complete suppression of cell division in this organism is brought about by approximately 0.1 M urethane. 4. Urethane concentrations up to 0.1 M affect primarily only one of the two postulated respiratory systems. The mechanism of the narcosis of cell division in this organism by urethane thus appears to be inhibition of this "activity" system. The Rockefeller University Press 1944-05-20 /pmc/articles/PMC2238023/ /pubmed/19873395 Text en Copyright © Copyright, 1944, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ormsbee, Richard A.
Fisher, Kenneth C.
THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII
title THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII
title_full THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII
title_fullStr THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII
title_full_unstemmed THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII
title_short THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII
title_sort effect of urethane on the consumption of oxygen and the rate of cell division in the ciliate tetrahymena geleii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238023/
https://www.ncbi.nlm.nih.gov/pubmed/19873395
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