Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes

BACKGROUND: Methionine aminopeptidase is a potential target of future antibacterial and anticancer drugs. Structural analysis of complexes of the enzyme with its inhibitors provides valuable information for structure-based drug design efforts. RESULTS: Five new X-ray structures of such enzyme-inhibi...

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Detalles Bibliográficos
Autores principales: Ma, Ze-Qiang, Xie, Sheng-Xue, Huang, Qing-Qing, Nan, Fa-Jun, Hurley, Thomas D, Ye, Qi-Zhuang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238726/
https://www.ncbi.nlm.nih.gov/pubmed/18093325
http://dx.doi.org/10.1186/1472-6807-7-84

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238726/
https://www.ncbi.nlm.nih.gov/pubmed/18093325
http://dx.doi.org/10.1186/1472-6807-7-84

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