Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions

Unexpected degradation of the P-C-P bridge from novel bisphosphonate derivative 1a and known etidronate trimethyl ester (1b) has been observed under mild reaction conditions. A proposed reaction mechanism for the unexpected degradation of 1a and 1b is also reported.

Detalles Bibliográficos
Autores principales: Turhanen, Petri A, Vepsäläinen, Jouko J
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2008
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238746/
https://www.ncbi.nlm.nih.gov/pubmed/18208588
http://dx.doi.org/10.1186/1860-5397-4-7
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author Turhanen, Petri A
Vepsäläinen, Jouko J
author_facet Turhanen, Petri A
Vepsäläinen, Jouko J
author_sort Turhanen, Petri A
collection PubMed
description Unexpected degradation of the P-C-P bridge from novel bisphosphonate derivative 1a and known etidronate trimethyl ester (1b) has been observed under mild reaction conditions. A proposed reaction mechanism for the unexpected degradation of 1a and 1b is also reported.
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spelling pubmed-22387462008-02-12 Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions Turhanen, Petri A Vepsäläinen, Jouko J Beilstein J Org Chem Full Research Paper Unexpected degradation of the P-C-P bridge from novel bisphosphonate derivative 1a and known etidronate trimethyl ester (1b) has been observed under mild reaction conditions. A proposed reaction mechanism for the unexpected degradation of 1a and 1b is also reported. Beilstein-Institut 2008-01-21 /pmc/articles/PMC2238746/ /pubmed/18208588 http://dx.doi.org/10.1186/1860-5397-4-7 Text en Copyright © 2008, Turhanen and Vepsäläinen https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Turhanen, Petri A
Vepsäläinen, Jouko J
Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions
title Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions
title_full Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions
title_fullStr Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions
title_full_unstemmed Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions
title_short Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions
title_sort unexpected degradation of the bisphosphonate p-c-p bridge under mild conditions
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238746/
https://www.ncbi.nlm.nih.gov/pubmed/18208588
http://dx.doi.org/10.1186/1860-5397-4-7
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