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DrugBank: a knowledgebase for drugs, drug actions and drug targets
DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in 2006, DrugBank has been widely used to facilitate in silico drug target discovery, drug design, drug docking or screening, drug metabolism p...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238889/ https://www.ncbi.nlm.nih.gov/pubmed/18048412 http://dx.doi.org/10.1093/nar/gkm958 |
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author | Wishart, David S. Knox, Craig Guo, An Chi Cheng, Dean Shrivastava, Savita Tzur, Dan Gautam, Bijaya Hassanali, Murtaza |
author_facet | Wishart, David S. Knox, Craig Guo, An Chi Cheng, Dean Shrivastava, Savita Tzur, Dan Gautam, Bijaya Hassanali, Murtaza |
author_sort | Wishart, David S. |
collection | PubMed |
description | DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in 2006, DrugBank has been widely used to facilitate in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmaceutical education. The latest version of DrugBank (release 2.0) has been expanded significantly over the previous release. With ∼4900 drug entries, it now contains 60% more FDA-approved small molecule and biotech drugs including 10% more ‘experimental’ drugs. Significantly, more protein target data has also been added to the database, with the latest version of DrugBank containing three times as many non-redundant protein or drug target sequences as before (1565 versus 524). Each DrugCard entry now contains more than 100 data fields with half of the information being devoted to drug/chemical data and the other half devoted to pharmacological, pharmacogenomic and molecular biological data. A number of new data fields, including food–drug interactions, drug–drug interactions and experimental ADME data have been added in response to numerous user requests. DrugBank has also significantly improved the power and simplicity of its structure query and text query searches. DrugBank is available at http://www.drugbank.ca |
format | Text |
id | pubmed-2238889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22388892008-02-12 DrugBank: a knowledgebase for drugs, drug actions and drug targets Wishart, David S. Knox, Craig Guo, An Chi Cheng, Dean Shrivastava, Savita Tzur, Dan Gautam, Bijaya Hassanali, Murtaza Nucleic Acids Res Articles DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in 2006, DrugBank has been widely used to facilitate in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmaceutical education. The latest version of DrugBank (release 2.0) has been expanded significantly over the previous release. With ∼4900 drug entries, it now contains 60% more FDA-approved small molecule and biotech drugs including 10% more ‘experimental’ drugs. Significantly, more protein target data has also been added to the database, with the latest version of DrugBank containing three times as many non-redundant protein or drug target sequences as before (1565 versus 524). Each DrugCard entry now contains more than 100 data fields with half of the information being devoted to drug/chemical data and the other half devoted to pharmacological, pharmacogenomic and molecular biological data. A number of new data fields, including food–drug interactions, drug–drug interactions and experimental ADME data have been added in response to numerous user requests. DrugBank has also significantly improved the power and simplicity of its structure query and text query searches. DrugBank is available at http://www.drugbank.ca Oxford University Press 2008-01 2007-11-29 /pmc/articles/PMC2238889/ /pubmed/18048412 http://dx.doi.org/10.1093/nar/gkm958 Text en © 2007 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Wishart, David S. Knox, Craig Guo, An Chi Cheng, Dean Shrivastava, Savita Tzur, Dan Gautam, Bijaya Hassanali, Murtaza DrugBank: a knowledgebase for drugs, drug actions and drug targets |
title | DrugBank: a knowledgebase for drugs, drug actions and drug targets |
title_full | DrugBank: a knowledgebase for drugs, drug actions and drug targets |
title_fullStr | DrugBank: a knowledgebase for drugs, drug actions and drug targets |
title_full_unstemmed | DrugBank: a knowledgebase for drugs, drug actions and drug targets |
title_short | DrugBank: a knowledgebase for drugs, drug actions and drug targets |
title_sort | drugbank: a knowledgebase for drugs, drug actions and drug targets |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238889/ https://www.ncbi.nlm.nih.gov/pubmed/18048412 http://dx.doi.org/10.1093/nar/gkm958 |
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