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BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence
The BioHealthBase Bioinformatics Resource Center (BRC) (http://www.biohealthbase.org) is a public bioinformatics database and analysis resource for the study of specific biodefense and public health pathogens—Influenza virus, Francisella tularensis, Mycobacterium tuberculosis, Microsporidia species...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238987/ https://www.ncbi.nlm.nih.gov/pubmed/17965094 http://dx.doi.org/10.1093/nar/gkm905 |
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author | Squires, Burke Macken, Catherine Garcia-Sastre, Adolfo Godbole, Shubhada Noronha, Jyothi Hunt, Victoria Chang, Roger Larsen, Christopher N. Klem, Ed Biersack, Kevin Scheuermann, Richard H. |
author_facet | Squires, Burke Macken, Catherine Garcia-Sastre, Adolfo Godbole, Shubhada Noronha, Jyothi Hunt, Victoria Chang, Roger Larsen, Christopher N. Klem, Ed Biersack, Kevin Scheuermann, Richard H. |
author_sort | Squires, Burke |
collection | PubMed |
description | The BioHealthBase Bioinformatics Resource Center (BRC) (http://www.biohealthbase.org) is a public bioinformatics database and analysis resource for the study of specific biodefense and public health pathogens—Influenza virus, Francisella tularensis, Mycobacterium tuberculosis, Microsporidia species and ricin toxin. The BioHealthBase serves as an extensive integrated repository of data imported from public databases, data derived from various computational algorithms and information curated from the scientific literature. The goal of the BioHealthBase is to facilitate the development of therapeutics, diagnostics and vaccines by integrating all available data in the context of host–pathogen interactions, thus allowing researchers to understand the root causes of virulence and pathogenicity. Genome and protein annotations can be viewed either as formatted text or graphically through a genome browser. 3D visualization capabilities allow researchers to view proteins with key structural and functional features highlighted. Influenza virus host–pathogen interactions at the molecular/cellular and systemic levels are represented. Host immune response to influenza infection is conveyed through the display of experimentally determined antibody and T-cell epitopes curated from the scientific literature or as derived from computational predictions. At the molecular/cellular level, the BioHealthBase BRC has developed biological pathway representations relevant to influenza virus host–pathogen interaction in collaboration with the Reactome database (http://www.reactome.org). |
format | Text |
id | pubmed-2238987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22389872008-02-12 BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence Squires, Burke Macken, Catherine Garcia-Sastre, Adolfo Godbole, Shubhada Noronha, Jyothi Hunt, Victoria Chang, Roger Larsen, Christopher N. Klem, Ed Biersack, Kevin Scheuermann, Richard H. Nucleic Acids Res Articles The BioHealthBase Bioinformatics Resource Center (BRC) (http://www.biohealthbase.org) is a public bioinformatics database and analysis resource for the study of specific biodefense and public health pathogens—Influenza virus, Francisella tularensis, Mycobacterium tuberculosis, Microsporidia species and ricin toxin. The BioHealthBase serves as an extensive integrated repository of data imported from public databases, data derived from various computational algorithms and information curated from the scientific literature. The goal of the BioHealthBase is to facilitate the development of therapeutics, diagnostics and vaccines by integrating all available data in the context of host–pathogen interactions, thus allowing researchers to understand the root causes of virulence and pathogenicity. Genome and protein annotations can be viewed either as formatted text or graphically through a genome browser. 3D visualization capabilities allow researchers to view proteins with key structural and functional features highlighted. Influenza virus host–pathogen interactions at the molecular/cellular and systemic levels are represented. Host immune response to influenza infection is conveyed through the display of experimentally determined antibody and T-cell epitopes curated from the scientific literature or as derived from computational predictions. At the molecular/cellular level, the BioHealthBase BRC has developed biological pathway representations relevant to influenza virus host–pathogen interaction in collaboration with the Reactome database (http://www.reactome.org). Oxford University Press 2008-01 2007-10-26 /pmc/articles/PMC2238987/ /pubmed/17965094 http://dx.doi.org/10.1093/nar/gkm905 Text en © 2007 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Squires, Burke Macken, Catherine Garcia-Sastre, Adolfo Godbole, Shubhada Noronha, Jyothi Hunt, Victoria Chang, Roger Larsen, Christopher N. Klem, Ed Biersack, Kevin Scheuermann, Richard H. BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence |
title | BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence |
title_full | BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence |
title_fullStr | BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence |
title_full_unstemmed | BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence |
title_short | BioHealthBase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence |
title_sort | biohealthbase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238987/ https://www.ncbi.nlm.nih.gov/pubmed/17965094 http://dx.doi.org/10.1093/nar/gkm905 |
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