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LeARN: a platform for detecting, clustering and annotating non-coding RNAs
BACKGROUND: In the last decade, sequencing projects have led to the development of a number of annotation systems dedicated to the structural and functional annotation of protein-coding genes. These annotation systems manage the annotation of the non-protein coding genes (ncRNAs) in a very crude way...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241582/ https://www.ncbi.nlm.nih.gov/pubmed/18194551 http://dx.doi.org/10.1186/1471-2105-9-21 |
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author | Noirot, Céline Gaspin, Christine Schiex, Thomas Gouzy, Jérôme |
author_facet | Noirot, Céline Gaspin, Christine Schiex, Thomas Gouzy, Jérôme |
author_sort | Noirot, Céline |
collection | PubMed |
description | BACKGROUND: In the last decade, sequencing projects have led to the development of a number of annotation systems dedicated to the structural and functional annotation of protein-coding genes. These annotation systems manage the annotation of the non-protein coding genes (ncRNAs) in a very crude way, allowing neither the edition of the secondary structures nor the clustering of ncRNA genes into families which are crucial for appropriate annotation of these molecules. RESULTS: LeARN is a flexible software package which handles the complete process of ncRNA annotation by integrating the layers of automatic detection and human curation. CONCLUSION: This software provides the infrastructure to deal properly with ncRNAs in the framework of any annotation project. It fills the gap between existing prediction software, that detect independent ncRNA occurrences, and public ncRNA repositories, that do not offer the flexibility and interactivity required for annotation projects. The software is freely available from the download section of the website |
format | Text |
id | pubmed-2241582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22415822008-02-13 LeARN: a platform for detecting, clustering and annotating non-coding RNAs Noirot, Céline Gaspin, Christine Schiex, Thomas Gouzy, Jérôme BMC Bioinformatics Software BACKGROUND: In the last decade, sequencing projects have led to the development of a number of annotation systems dedicated to the structural and functional annotation of protein-coding genes. These annotation systems manage the annotation of the non-protein coding genes (ncRNAs) in a very crude way, allowing neither the edition of the secondary structures nor the clustering of ncRNA genes into families which are crucial for appropriate annotation of these molecules. RESULTS: LeARN is a flexible software package which handles the complete process of ncRNA annotation by integrating the layers of automatic detection and human curation. CONCLUSION: This software provides the infrastructure to deal properly with ncRNAs in the framework of any annotation project. It fills the gap between existing prediction software, that detect independent ncRNA occurrences, and public ncRNA repositories, that do not offer the flexibility and interactivity required for annotation projects. The software is freely available from the download section of the website BioMed Central 2008-01-14 /pmc/articles/PMC2241582/ /pubmed/18194551 http://dx.doi.org/10.1186/1471-2105-9-21 Text en Copyright © 2008 Noirot et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Software Noirot, Céline Gaspin, Christine Schiex, Thomas Gouzy, Jérôme LeARN: a platform for detecting, clustering and annotating non-coding RNAs |
title | LeARN: a platform for detecting, clustering and annotating non-coding RNAs |
title_full | LeARN: a platform for detecting, clustering and annotating non-coding RNAs |
title_fullStr | LeARN: a platform for detecting, clustering and annotating non-coding RNAs |
title_full_unstemmed | LeARN: a platform for detecting, clustering and annotating non-coding RNAs |
title_short | LeARN: a platform for detecting, clustering and annotating non-coding RNAs |
title_sort | learn: a platform for detecting, clustering and annotating non-coding rnas |
topic | Software |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241582/ https://www.ncbi.nlm.nih.gov/pubmed/18194551 http://dx.doi.org/10.1186/1471-2105-9-21 |
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