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Improved functional expression of recombinant human ether-a-go-go (hERG) K(+ )channels by cultivation at reduced temperature

BACKGROUND: HERG potassium channel blockade is the major cause for drug-induced long QT syndrome, which sometimes cause cardiac disrhythmias and sudden death. There is a strong interest in the pharmaceutical industry to develop high quality medium to high-throughput assays for detecting compounds wi...

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Detalles Bibliográficos
Autores principales:	Chen, Mao Xiang, Sandow, Shaun L, Doceul, Virginie, Chen, Yu Hua, Harper, Heather, Hamilton, Bruce, Meadows, Helen J, Trezise, Derek J, Clare, Jeff J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241608/ https://www.ncbi.nlm.nih.gov/pubmed/18096051 http://dx.doi.org/10.1186/1472-6750-7-93

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