Cargando…
Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge
BACKGROUND: It is thought that excessive alcohol consumption is related to the high mortality among working age men in Russia. Moreover it has been suggested that alcohol is a key proximate driver of the very sharp fluctuations in mortality seen in this group since the mid-1980s. Designing an indivi...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241617/ https://www.ncbi.nlm.nih.gov/pubmed/18045487 http://dx.doi.org/10.1186/1471-2458-7-343 |
_version_ | 1782150521978617856 |
---|---|
author | Tomkins, Susannah Shkolnikov, Vladimir Andreev, Evgueni Kiryanov, Nikolay Leon, David A McKee, Martin Saburova, Lyudmila |
author_facet | Tomkins, Susannah Shkolnikov, Vladimir Andreev, Evgueni Kiryanov, Nikolay Leon, David A McKee, Martin Saburova, Lyudmila |
author_sort | Tomkins, Susannah |
collection | PubMed |
description | BACKGROUND: It is thought that excessive alcohol consumption is related to the high mortality among working age men in Russia. Moreover it has been suggested that alcohol is a key proximate driver of the very sharp fluctuations in mortality seen in this group since the mid-1980s. Designing an individual-level study suitable to address the potential acute effects of alcohol consumption on mortality in Russia has posed a challenge to epidemiologists, especially because of the need to identify factors that could underlie the rapid changes up and down in mortality rates that have been such a distinctive feature of the Russian mortality crisis. In order to address this study question which focuses on exposures acting shortly before sudden death, a cohort would be unfeasibly large and would suffer from recruitment bias. METHODS: Although the situation in Russia is unusual, with a very high death rate characterised by many sudden and apparently unexpected deaths in young men, the methodological problem is common to research on any cause of death where many deaths are sudden. RESULTS: We describe the development of an innovative approach that has overcome some of these challenges: a case-control study employing proxy informants and external data sources to collect information about proximate determinants of mortality. CONCLUSION: This offers a set of principles that can be adopted by epidemiologists studying sudden and unexpected deaths in other settings. |
format | Text |
id | pubmed-2241617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22416172008-02-13 Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge Tomkins, Susannah Shkolnikov, Vladimir Andreev, Evgueni Kiryanov, Nikolay Leon, David A McKee, Martin Saburova, Lyudmila BMC Public Health Correspondence BACKGROUND: It is thought that excessive alcohol consumption is related to the high mortality among working age men in Russia. Moreover it has been suggested that alcohol is a key proximate driver of the very sharp fluctuations in mortality seen in this group since the mid-1980s. Designing an individual-level study suitable to address the potential acute effects of alcohol consumption on mortality in Russia has posed a challenge to epidemiologists, especially because of the need to identify factors that could underlie the rapid changes up and down in mortality rates that have been such a distinctive feature of the Russian mortality crisis. In order to address this study question which focuses on exposures acting shortly before sudden death, a cohort would be unfeasibly large and would suffer from recruitment bias. METHODS: Although the situation in Russia is unusual, with a very high death rate characterised by many sudden and apparently unexpected deaths in young men, the methodological problem is common to research on any cause of death where many deaths are sudden. RESULTS: We describe the development of an innovative approach that has overcome some of these challenges: a case-control study employing proxy informants and external data sources to collect information about proximate determinants of mortality. CONCLUSION: This offers a set of principles that can be adopted by epidemiologists studying sudden and unexpected deaths in other settings. BioMed Central 2007-11-28 /pmc/articles/PMC2241617/ /pubmed/18045487 http://dx.doi.org/10.1186/1471-2458-7-343 Text en Copyright © 2007 Tomkins et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Correspondence Tomkins, Susannah Shkolnikov, Vladimir Andreev, Evgueni Kiryanov, Nikolay Leon, David A McKee, Martin Saburova, Lyudmila Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge |
title | Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge |
title_full | Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge |
title_fullStr | Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge |
title_full_unstemmed | Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge |
title_short | Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge |
title_sort | identifying the determinants of premature mortality in russia: overcoming a methodological challenge |
topic | Correspondence |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241617/ https://www.ncbi.nlm.nih.gov/pubmed/18045487 http://dx.doi.org/10.1186/1471-2458-7-343 |
work_keys_str_mv | AT tomkinssusannah identifyingthedeterminantsofprematuremortalityinrussiaovercomingamethodologicalchallenge AT shkolnikovvladimir identifyingthedeterminantsofprematuremortalityinrussiaovercomingamethodologicalchallenge AT andreevevgueni identifyingthedeterminantsofprematuremortalityinrussiaovercomingamethodologicalchallenge AT kiryanovnikolay identifyingthedeterminantsofprematuremortalityinrussiaovercomingamethodologicalchallenge AT leondavida identifyingthedeterminantsofprematuremortalityinrussiaovercomingamethodologicalchallenge AT mckeemartin identifyingthedeterminantsofprematuremortalityinrussiaovercomingamethodologicalchallenge AT saburovalyudmila identifyingthedeterminantsofprematuremortalityinrussiaovercomingamethodologicalchallenge |