Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn(2+)-binding motif and molecular modelling

BACKGROUND: Aminopeptidase B (Ap-B; EC 3.4.11.6) catalyzes the cleavage of basic residues at the N-terminus of peptides and processes glucagon into miniglucagon. The enzyme exhibits, in vitro, a residual ability to hydrolyze leukotriene A(4 )into the pro-inflammatory lipid mediator leukotriene B(4)....

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Detalles Bibliográficos
Autores principales: Pham, Viet-Laï, Cadel, Marie-Sandrine, Gouzy-Darmon, Cécile, Hanquez, Chantal, Beinfeld, Margery C, Nicolas, Pierre, Etchebest, Catherine, Foulon, Thierry
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241622/
https://www.ncbi.nlm.nih.gov/pubmed/17974014
http://dx.doi.org/10.1186/1471-2091-8-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241622/
https://www.ncbi.nlm.nih.gov/pubmed/17974014
http://dx.doi.org/10.1186/1471-2091-8-21

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