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Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn(2+)-binding motif and molecular modelling
BACKGROUND: Aminopeptidase B (Ap-B; EC 3.4.11.6) catalyzes the cleavage of basic residues at the N-terminus of peptides and processes glucagon into miniglucagon. The enzyme exhibits, in vitro, a residual ability to hydrolyze leukotriene A(4 )into the pro-inflammatory lipid mediator leukotriene B(4)....
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241622/ https://www.ncbi.nlm.nih.gov/pubmed/17974014 http://dx.doi.org/10.1186/1471-2091-8-21 |