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The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient
Approximately 30% of human tumors characterized to date express DNA polymerase beta (pol β) variant proteins. Two of the polymerase beta cancer-associated variants are sequence-specific mutators, and one of them binds to DNA but has no polymerase activity. The Leu22Pro (L22P) DNA polymerase beta var...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241857/ https://www.ncbi.nlm.nih.gov/pubmed/18039710 http://dx.doi.org/10.1093/nar/gkm1053 |