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The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient

Approximately 30% of human tumors characterized to date express DNA polymerase beta (pol β) variant proteins. Two of the polymerase beta cancer-associated variants are sequence-specific mutators, and one of them binds to DNA but has no polymerase activity. The Leu22Pro (L22P) DNA polymerase beta var...

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Detalles Bibliográficos
Autores principales:	Dalal, Shibani, Chikova, Anna, Jaeger, Joachim, Sweasy, Joann B.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241857/ https://www.ncbi.nlm.nih.gov/pubmed/18039710 http://dx.doi.org/10.1093/nar/gkm1053

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