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Repair of DNA double-strand breaks within the (GAA•TTC)(n) sequence results in frequent deletion of the triplet-repeat sequence

Friedreich ataxia is caused by an expanded (GAA•TTC)(n) sequence, which is unstable during intergenerational transmission and in most patient tissues, where it frequently undergoes large deletions. We investigated the effect of DSB repair on instability of the (GAA•TTC)(n) sequence. Linear plasmids...

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Detalles Bibliográficos
Autores principales:	Pollard, Laura M., Bourn, Rebecka L., Bidichandani, Sanjay I.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241870/ https://www.ncbi.nlm.nih.gov/pubmed/18045804 http://dx.doi.org/10.1093/nar/gkm1066

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