Structure–function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement

The active center clefts of RNA polymerase (RNAP) from the archaeon Pyrococcus furiosus (Pfu) and of yeast RNAP II are nearly identical, including four protruding loops, the lid, rudder, fork 1 and fork 2. Here we present a structure–function analysis of recombinant Pfu RNAP variants lacking these c...

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Detalles Bibliográficos
Autores principales: Naji, Souad, Bertero, Michela G., Spitalny, Patrizia, Cramer, Patrick, Thomm, Michael
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241882/
https://www.ncbi.nlm.nih.gov/pubmed/18073196
http://dx.doi.org/10.1093/nar/gkm1086

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