Rapid peptide-based screening on the substrate specificity of severe acute respiratory syndrome (SARS) coronavirus 3C-like protease by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like protease (3CL(pro)) mediates extensive proteolytic processing of replicase polyproteins, and is considered a promising target for anti-SARS drug development. Here we present a rapid and high-throughput screening method to study the sub...

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Detalles Bibliográficos
Autores principales: Chu, Ling-Hon Matthew, Choy, Wai-Yan, Tsai, Sau-Na, Rao, Zihe, Ngai, Sai-Ming
Formato: Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242481/
https://www.ncbi.nlm.nih.gov/pubmed/16600962
http://dx.doi.org/10.1110/ps.052007306

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