Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy

INTRODUCTION: Basal-like breast cancers (BLBCs) are very aggressive, and present serious clinical challenges as there are currently no targeted therapies available. We determined the regulatory role of Y-box binding protein-1 (YB-1) on epidermal growth factor receptor (EGFR) overexpression in BLBC,...

Descripción completa

Detalles Bibliográficos
Autores principales: Stratford, Anna L, Habibi, Golareh, Astanehe, Arezoo, Jiang, Helen, Hu, Kaiji, Park, Eugene, Shadeo, Ashleen, Buys, Timon PH, Lam, Wan, Pugh, Trevor, Marra, Marco, Nielsen, Torsten O, Klinge, Uwe, Mertens, Peter R, Aparicio, Samuel, Dunn, Sandra E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242657/
https://www.ncbi.nlm.nih.gov/pubmed/17875215
http://dx.doi.org/10.1186/bcr1767

Ejemplares similares

Ejemplares similares