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How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

Upon cell adhesion, talin physically couples the cytoskeleton via integrins to the extracellular matrix, and subsequent vinculin recruitment is enhanced by locally applied tensile force. Since the vinculin binding (VB) sites are buried in the talin rod under equilibrium conditions, the structural me...

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Detalles Bibliográficos
Autores principales:	Hytönen, Vesa P, Vogel, Viola
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242828/ https://www.ncbi.nlm.nih.gov/pubmed/18282082 http://dx.doi.org/10.1371/journal.pcbi.0040024

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