A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

Chikungunya virus (CHIKV) is a re-emerging arbovirus responsible for a massive outbreak currently afflicting the Indian Ocean region and India. Infection from CHIKV typically induces a mild disease in humans, characterized by fever, myalgia, arthralgia, and rash. Cases of severe CHIKV infection invo...

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Detalles Bibliográficos
Autores principales: Couderc, Thérèse, Chrétien, Fabrice, Schilte, Clémentine, Disson, Olivier, Brigitte, Madly, Guivel-Benhassine, Florence, Touret, Yasmina, Barau, Georges, Cayet, Nadège, Schuffenecker, Isabelle, Desprès, Philippe, Arenzana-Seisdedos, Fernando, Michault, Alain, Albert, Matthew L, Lecuit, Marc
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242832/
https://www.ncbi.nlm.nih.gov/pubmed/18282093
http://dx.doi.org/10.1371/journal.ppat.0040029

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