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Synthetic Biology of Proteins: Tuning GFPs Folding and Stability with Fluoroproline

BACKGROUND: Proline residues affect protein folding and stability via cis/trans isomerization of peptide bonds and by the C(γ)-exo or -endo puckering of their pyrrolidine rings. Peptide bond conformation as well as puckering propensity can be manipulated by proper choice of ring substituents, e.g. C...

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Detalles Bibliográficos
Autores principales:	Steiner, Thomas, Hess, Petra, Bae, Jae Hyun, Wiltschi, Birgit, Moroder, Luis, Budisa, Nediljko
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243022/ https://www.ncbi.nlm.nih.gov/pubmed/18301757 http://dx.doi.org/10.1371/journal.pone.0001680

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