Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma

Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following...

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Autores principales: Murphy, N C, Scarlett, C J, Kench, J G, Sum, E Y M, Segara, D, Colvin, E K, Susanto, J, Cosman, P H, Lee, C-S, Musgrove, E A, Sutherland, R L, Lindeman, G J, Henshall, S M, Visvader, J E, Biankin, A V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243155/
https://www.ncbi.nlm.nih.gov/pubmed/18231110
http://dx.doi.org/10.1038/sj.bjc.6604177
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author Murphy, N C
Scarlett, C J
Kench, J G
Sum, E Y M
Segara, D
Colvin, E K
Susanto, J
Cosman, P H
Lee, C-S
Musgrove, E A
Sutherland, R L
Lindeman, G J
Henshall, S M
Visvader, J E
Biankin, A V
author_facet Murphy, N C
Scarlett, C J
Kench, J G
Sum, E Y M
Segara, D
Colvin, E K
Susanto, J
Cosman, P H
Lee, C-S
Musgrove, E A
Sutherland, R L
Lindeman, G J
Henshall, S M
Visvader, J E
Biankin, A V
author_sort Murphy, N C
collection PubMed
description Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resection, whereas the survival of those patients whose tumours had low or no LMO4 expression was not significantly different when resection was compared with operative biopsy alone.
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spelling pubmed-22431552009-09-10 Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma Murphy, N C Scarlett, C J Kench, J G Sum, E Y M Segara, D Colvin, E K Susanto, J Cosman, P H Lee, C-S Musgrove, E A Sutherland, R L Lindeman, G J Henshall, S M Visvader, J E Biankin, A V Br J Cancer Clinical Study Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resection, whereas the survival of those patients whose tumours had low or no LMO4 expression was not significantly different when resection was compared with operative biopsy alone. Nature Publishing Group 2008-02-12 2008-01-29 /pmc/articles/PMC2243155/ /pubmed/18231110 http://dx.doi.org/10.1038/sj.bjc.6604177 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical Study
Murphy, N C
Scarlett, C J
Kench, J G
Sum, E Y M
Segara, D
Colvin, E K
Susanto, J
Cosman, P H
Lee, C-S
Musgrove, E A
Sutherland, R L
Lindeman, G J
Henshall, S M
Visvader, J E
Biankin, A V
Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma
title Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma
title_full Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma
title_fullStr Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma
title_full_unstemmed Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma
title_short Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma
title_sort expression of lmo4 and outcome in pancreatic ductal adenocarcinoma
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243155/
https://www.ncbi.nlm.nih.gov/pubmed/18231110
http://dx.doi.org/10.1038/sj.bjc.6604177
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