Cargando…
The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease
BACKGROUND: Statins improve the endothelial function in patients with coronary artery disease (CAD). However, they contribute to the substantial decrease in coronary heart disease by reducing plasma cholesterol levels. They also, reduce oxidative stress, stabilize the atherosclerotic plaque and inhi...
Autores principales: | , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245917/ https://www.ncbi.nlm.nih.gov/pubmed/18163915 http://dx.doi.org/10.1186/1476-7120-5-51 |
_version_ | 1782150684504752128 |
---|---|
author | Yildiz, Ahmet Cakar, M Akif Baskurt, Murat Okcun, Barıs Guzelsoy, Deniz Coskun, Ugur |
author_facet | Yildiz, Ahmet Cakar, M Akif Baskurt, Murat Okcun, Barıs Guzelsoy, Deniz Coskun, Ugur |
author_sort | Yildiz, Ahmet |
collection | PubMed |
description | BACKGROUND: Statins improve the endothelial function in patients with coronary artery disease (CAD). However, they contribute to the substantial decrease in coronary heart disease by reducing plasma cholesterol levels. They also, reduce oxidative stress, stabilize the atherosclerotic plaque and inhibit inflammatory response. These functions of statins have been briefly described as pleiotropic effects. The aim of our study was to evaluate the effect of atorvastatin therapy on endothelial functions in patients with CAD. METHODS: Fourty-nine patients (40 men, 9 women, mean age 59 +/- 11 years) with diagnosed CAD were selected as the study group. The patients were given 10 mg/day atorvastatin for 12 weeks. If the target cholesterol levels has not been achieved 6 weeks after the treatment, then the daily atorvastatin dosage has been increased. The endothelial function was evaluated by flow mediated dilatation (FMD) of the brachial artery. RESULTS: It has been figured out that 12 weeks later, atorvastatin caused a statistically significant decrease in the plasma levels of LDL-cholesterol and total cholesterol (p < 0,0001). Meanwhile, it was determined that the FMD got statistically significant improved 12 weeks after the atorvastatin therapy (8,1%–4,2%, p < 0,001). However there was no statistically significant change in non-endothelium dependent dilatation (NID). CONCLUSION: Endothelium derived vasodilatation (EBD), which was non-invasively detected via brachial artery ultrasonography, had statistically significant improvment within 12 weeks of atorvastatin therapy whereas non-endothelium dependent dilatation (NID) had no change. |
format | Text |
id | pubmed-2245917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22459172008-02-16 The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease Yildiz, Ahmet Cakar, M Akif Baskurt, Murat Okcun, Barıs Guzelsoy, Deniz Coskun, Ugur Cardiovasc Ultrasound Technical Notes BACKGROUND: Statins improve the endothelial function in patients with coronary artery disease (CAD). However, they contribute to the substantial decrease in coronary heart disease by reducing plasma cholesterol levels. They also, reduce oxidative stress, stabilize the atherosclerotic plaque and inhibit inflammatory response. These functions of statins have been briefly described as pleiotropic effects. The aim of our study was to evaluate the effect of atorvastatin therapy on endothelial functions in patients with CAD. METHODS: Fourty-nine patients (40 men, 9 women, mean age 59 +/- 11 years) with diagnosed CAD were selected as the study group. The patients were given 10 mg/day atorvastatin for 12 weeks. If the target cholesterol levels has not been achieved 6 weeks after the treatment, then the daily atorvastatin dosage has been increased. The endothelial function was evaluated by flow mediated dilatation (FMD) of the brachial artery. RESULTS: It has been figured out that 12 weeks later, atorvastatin caused a statistically significant decrease in the plasma levels of LDL-cholesterol and total cholesterol (p < 0,0001). Meanwhile, it was determined that the FMD got statistically significant improved 12 weeks after the atorvastatin therapy (8,1%–4,2%, p < 0,001). However there was no statistically significant change in non-endothelium dependent dilatation (NID). CONCLUSION: Endothelium derived vasodilatation (EBD), which was non-invasively detected via brachial artery ultrasonography, had statistically significant improvment within 12 weeks of atorvastatin therapy whereas non-endothelium dependent dilatation (NID) had no change. BioMed Central 2007-12-30 /pmc/articles/PMC2245917/ /pubmed/18163915 http://dx.doi.org/10.1186/1476-7120-5-51 Text en Copyright © 2007 Yildiz et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Technical Notes Yildiz, Ahmet Cakar, M Akif Baskurt, Murat Okcun, Barıs Guzelsoy, Deniz Coskun, Ugur The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease |
title | The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease |
title_full | The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease |
title_fullStr | The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease |
title_full_unstemmed | The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease |
title_short | The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease |
title_sort | effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease |
topic | Technical Notes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245917/ https://www.ncbi.nlm.nih.gov/pubmed/18163915 http://dx.doi.org/10.1186/1476-7120-5-51 |
work_keys_str_mv | AT yildizahmet theeffectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT cakarmakif theeffectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT baskurtmurat theeffectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT okcunbarıs theeffectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT guzelsoydeniz theeffectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT coskunugur theeffectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT yildizahmet effectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT cakarmakif effectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT baskurtmurat effectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT okcunbarıs effectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT guzelsoydeniz effectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease AT coskunugur effectsofatorvastatintherapyonendothelıalfunctioninpatientswithcoronaryarterydisease |