Mitigating Mutational Meltdown in Mammalian Mitochondria

Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function.

Detalles Bibliográficos
Autor principal: Rand, David M
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245988/
https://www.ncbi.nlm.nih.gov/pubmed/18288890
http://dx.doi.org/10.1371/journal.pbio.0060035
Descripción
Sumario:Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function.

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