Mitigating Mutational Meltdown in Mammalian Mitochondria

Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function.

Detalles Bibliográficos
Autor principal: Rand, David M
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245988/
https://www.ncbi.nlm.nih.gov/pubmed/18288890
http://dx.doi.org/10.1371/journal.pbio.0060035
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author Rand, David M
author_facet Rand, David M
author_sort Rand, David M
collection PubMed
description Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function.
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spelling pubmed-22459882008-02-19 Mitigating Mutational Meltdown in Mammalian Mitochondria Rand, David M PLoS Biol Primer Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function. Public Library of Science 2008-02 2008-02-19 /pmc/articles/PMC2245988/ /pubmed/18288890 http://dx.doi.org/10.1371/journal.pbio.0060035 Text en © 2008 David M. Rand. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Primer
Rand, David M
Mitigating Mutational Meltdown in Mammalian Mitochondria
title Mitigating Mutational Meltdown in Mammalian Mitochondria
title_full Mitigating Mutational Meltdown in Mammalian Mitochondria
title_fullStr Mitigating Mutational Meltdown in Mammalian Mitochondria
title_full_unstemmed Mitigating Mutational Meltdown in Mammalian Mitochondria
title_short Mitigating Mutational Meltdown in Mammalian Mitochondria
title_sort mitigating mutational meltdown in mammalian mitochondria
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245988/
https://www.ncbi.nlm.nih.gov/pubmed/18288890
http://dx.doi.org/10.1371/journal.pbio.0060035
work_keys_str_mv AT randdavidm mitigatingmutationalmeltdowninmammalianmitochondria

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