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Mitigating Mutational Meltdown in Mammalian Mitochondria
Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function.
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245988/ https://www.ncbi.nlm.nih.gov/pubmed/18288890 http://dx.doi.org/10.1371/journal.pbio.0060035 |