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PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility

Peroxisome proliferator-activated receptor gamma (PPARG) regulates cellular functions such as adipogenesis and immune cell activation. However, new information has indicated additional roles of PPARG directing the cyclic changes that occur within ovarian tissue of female mammals, including those tha...

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Detalles Bibliográficos
Autores principales: Minge, Cadence E., Robker, Rebecca L., Norman, Robert J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246065/
https://www.ncbi.nlm.nih.gov/pubmed/18309368
http://dx.doi.org/10.1155/2008/243791
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author Minge, Cadence E.
Robker, Rebecca L.
Norman, Robert J.
author_facet Minge, Cadence E.
Robker, Rebecca L.
Norman, Robert J.
author_sort Minge, Cadence E.
collection PubMed
description Peroxisome proliferator-activated receptor gamma (PPARG) regulates cellular functions such as adipogenesis and immune cell activation. However, new information has indicated additional roles of PPARG directing the cyclic changes that occur within ovarian tissue of female mammals, including those that facilitate the release of oocytes each estrous cycle. In addition to ovarian PPARG expression and function, many PPARG actions within adipocytes and macrophages have additional direct and indirect implications for ovarian function and female fertility. This encompasses the regulation of lipid uptake and transport, insulin sensitivity, glucose metabolism, and the regulation of inflammatory mediator synthesis and release. This review discusses the developing links between PPARG activity and female reproductive function, and highlights several mechanisms that may facilitate such a relationship.
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spelling pubmed-22460652008-02-28 PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility Minge, Cadence E. Robker, Rebecca L. Norman, Robert J. PPAR Res Review Article Peroxisome proliferator-activated receptor gamma (PPARG) regulates cellular functions such as adipogenesis and immune cell activation. However, new information has indicated additional roles of PPARG directing the cyclic changes that occur within ovarian tissue of female mammals, including those that facilitate the release of oocytes each estrous cycle. In addition to ovarian PPARG expression and function, many PPARG actions within adipocytes and macrophages have additional direct and indirect implications for ovarian function and female fertility. This encompasses the regulation of lipid uptake and transport, insulin sensitivity, glucose metabolism, and the regulation of inflammatory mediator synthesis and release. This review discusses the developing links between PPARG activity and female reproductive function, and highlights several mechanisms that may facilitate such a relationship. Hindawi Publishing Corporation 2008 2008-01-03 /pmc/articles/PMC2246065/ /pubmed/18309368 http://dx.doi.org/10.1155/2008/243791 Text en Copyright © 2008 Cadence E. Minge et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Minge, Cadence E.
Robker, Rebecca L.
Norman, Robert J.
PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
title PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
title_full PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
title_fullStr PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
title_full_unstemmed PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
title_short PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
title_sort ppar gamma: coordinating metabolic and immune contributions to female fertility
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246065/
https://www.ncbi.nlm.nih.gov/pubmed/18309368
http://dx.doi.org/10.1155/2008/243791
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