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Breast tumour angiogenesis
The central importance of tumour neovascularization has been emphasized by clinical trials using antiangiogenic therapy in breast cancer. This review gives a background to breast tumour neovascularization in in situ and invasive breast cancer, outlines the mechanisms by which this is achieved and di...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246178/ https://www.ncbi.nlm.nih.gov/pubmed/18190723 http://dx.doi.org/10.1186/bcr1796 |
| _version_ | 1782150733693452288 |
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| author | Fox, Stephen B Generali, Daniele G Harris, Adrian L |
| author_facet | Fox, Stephen B Generali, Daniele G Harris, Adrian L |
| author_sort | Fox, Stephen B |
| collection | PubMed |
| description | The central importance of tumour neovascularization has been emphasized by clinical trials using antiangiogenic therapy in breast cancer. This review gives a background to breast tumour neovascularization in in situ and invasive breast cancer, outlines the mechanisms by which this is achieved and discusses the influence of the microenvironment, focusing on hypoxia. The regulation of angiogenesis and the antivascular agents that are used in an antiangiogenic dosing schedule, both novel and conventional, are also summarized. |
| format | Text |
| id | pubmed-2246178 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2007 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-22461782008-02-20 Breast tumour angiogenesis Fox, Stephen B Generali, Daniele G Harris, Adrian L Breast Cancer Res Review The central importance of tumour neovascularization has been emphasized by clinical trials using antiangiogenic therapy in breast cancer. This review gives a background to breast tumour neovascularization in in situ and invasive breast cancer, outlines the mechanisms by which this is achieved and discusses the influence of the microenvironment, focusing on hypoxia. The regulation of angiogenesis and the antivascular agents that are used in an antiangiogenic dosing schedule, both novel and conventional, are also summarized. BioMed Central 2007 2007-12-18 /pmc/articles/PMC2246178/ /pubmed/18190723 http://dx.doi.org/10.1186/bcr1796 Text en Copyright © 2007 BioMed Central Ltd |
| spellingShingle | Review Fox, Stephen B Generali, Daniele G Harris, Adrian L Breast tumour angiogenesis |
| title | Breast tumour angiogenesis |
| title_full | Breast tumour angiogenesis |
| title_fullStr | Breast tumour angiogenesis |
| title_full_unstemmed | Breast tumour angiogenesis |
| title_short | Breast tumour angiogenesis |
| title_sort | breast tumour angiogenesis |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246178/ https://www.ncbi.nlm.nih.gov/pubmed/18190723 http://dx.doi.org/10.1186/bcr1796 |
| work_keys_str_mv | AT foxstephenb breasttumourangiogenesis AT generalidanieleg breasttumourangiogenesis AT harrisadrianl breasttumourangiogenesis |