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Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

INTRODUCTION: Hypoxia-inducible factor (HIF)-1α levels in invasive breast carcinoma have been shown to be an adverse prognostic indicator. Cellular HIF-1α activity is regulated by factor-inhibiting hypoxia-inducible factor 1 (FIH-1). In hypoxia, FIH-1 hydroxylation of Asn803 within the C-terminal tr...

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Detalles Bibliográficos
Autores principales:	Tan, Ern Yu, Campo, Leticia, Han, Cheng, Turley, Helen, Pezzella, Francesco, Gatter, Kevin C, Harris, Adrian L, Fox, Stephen B
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246192/ https://www.ncbi.nlm.nih.gov/pubmed/18096060 http://dx.doi.org/10.1186/bcr1838

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