Gene expression profiling of Hfe(-/- )liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers

BACKGROUND: Hfe disruption in mouse leads to experimental hemochromatosis by a mechanism that remains elusive. Affymetrix GeneChip(® )Mouse Genome 430 2.0 microarrays and bioinformatics tools were used to characterize patterns of gene expression in the liver and the duodenum of wild-type and Hfe-def...

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Detalles Bibliográficos
Autores principales: Coppin, Hélène, Darnaud, Valérie, Kautz, Léon, Meynard, Delphine, Aubry, Marc, Mosser, Jean, Martinez, Maria, Roth, Marie-Paule
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246295/
https://www.ncbi.nlm.nih.gov/pubmed/17945001
http://dx.doi.org/10.1186/gb-2007-8-10-r221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246295/
https://www.ncbi.nlm.nih.gov/pubmed/17945001
http://dx.doi.org/10.1186/gb-2007-8-10-r221

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