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Gene expression profiling of Hfe(-/- )liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers
BACKGROUND: Hfe disruption in mouse leads to experimental hemochromatosis by a mechanism that remains elusive. Affymetrix GeneChip(® )Mouse Genome 430 2.0 microarrays and bioinformatics tools were used to characterize patterns of gene expression in the liver and the duodenum of wild-type and Hfe-def...
Autores principales: | Coppin, Hélène, Darnaud, Valérie, Kautz, Léon, Meynard, Delphine, Aubry, Marc, Mosser, Jean, Martinez, Maria, Roth, Marie-Paule |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246295/ https://www.ncbi.nlm.nih.gov/pubmed/17945001 http://dx.doi.org/10.1186/gb-2007-8-10-r221 |
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