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Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools

BACKGROUND: The phenomenon of functional site turnover has important implications for the study of regulatory region evolution, such as for promoter sequence alignments and transcription factor binding site (TFBS) identification. At present, it remains difficult to estimate TFBS turnover rates on re...

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Detalles Bibliográficos
Autores principales:	Huang, Weichun, Nevins, Joseph R, Ohler, Uwe
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246299/ https://www.ncbi.nlm.nih.gov/pubmed/17956628 http://dx.doi.org/10.1186/gb-2007-8-10-r225

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