A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding

Phosphoinositides have crucial roles in cellular controls, many of which have been established through the use of small-molecule inhibitors. Here, we describe YM201636, a potent inhibitor of the mammalian class III phosphatidylinositol phosphate kinase PIKfyve, which synthesizes phosphatidylinositol...

Descripción completa

Detalles Bibliográficos
Autores principales: Jefferies, Harold B J, Cooke, Frank T, Jat, Parmjit, Boucheron, Christine, Koizumi, Tomonobu, Hayakawa, Masahiko, Kaizawa, Hiroyuki, Ohishi, Takahide, Workman, Paul, Waterfield, Michael D, Parker, Peter J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Scientific Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246419/
https://www.ncbi.nlm.nih.gov/pubmed/18188180
http://dx.doi.org/10.1038/sj.embor.7401155

Ejemplares similares

Ejemplares similares